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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PMS1
All Species:
13.03
Human Site:
Y235
Identified Species:
26.06
UniProt:
P54277
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54277
NP_000525.1
932
105830
Y235
H
S
E
E
S
Q
I
Y
L
S
G
F
L
P
K
Chimpanzee
Pan troglodytes
XP_515987
1061
120272
Y364
H
S
E
E
S
Q
I
Y
L
S
G
F
L
P
K
Rhesus Macaque
Macaca mulatta
XP_001103074
831
93641
V191
P
D
L
R
I
V
F
V
H
N
K
A
V
I
W
Dog
Lupus familis
XP_536002
930
105612
Y235
H
P
E
D
S
Q
I
Y
L
S
G
F
L
P
K
Cat
Felis silvestris
Mouse
Mus musculus
P54279
859
95207
V215
Q
G
K
R
H
A
V
V
C
T
S
G
T
S
G
Rat
Rattus norvegicus
NP_001009535
919
103710
H235
Y
C
E
D
S
Q
I
H
L
R
G
L
F
P
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507554
871
92244
Y227
D
N
L
A
P
F
Q
Y
Q
S
A
D
S
E
M
Chicken
Gallus gallus
NP_001006508
916
103017
H227
G
S
M
V
P
F
Q
H
C
C
E
D
P
E
I
Frog
Xenopus laevis
NP_001079545
925
103654
S235
Q
S
E
A
P
E
I
S
I
N
G
Y
L
P
K
Zebra Danio
Brachydanio rerio
NP_958476
896
98728
H227
A
N
M
L
P
V
Q
H
H
Q
E
Q
P
E
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001188203
734
80915
G94
L
I
T
Y
G
F
R
G
E
A
L
G
S
L
C
Poplar Tree
Populus trichocarpa
XP_002321013
915
101109
E233
V
N
T
F
S
C
L
E
P
V
D
I
D
I
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.4
86.2
83.6
N.A.
22.3
73.7
N.A.
35.9
58.3
50.7
46.1
N.A.
N.A.
N.A.
N.A.
28.3
Protein Similarity:
100
87.7
87.7
92.6
N.A.
41.6
86
N.A.
50.7
74.6
69
64.6
N.A.
N.A.
N.A.
N.A.
45.8
P-Site Identity:
100
100
0
86.6
N.A.
0
53.3
N.A.
13.3
6.6
46.6
0
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
13.3
93.3
N.A.
20
73.3
N.A.
20
13.3
73.3
13.3
N.A.
N.A.
N.A.
N.A.
6.6
Percent
Protein Identity:
23.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
45.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
20
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
17
0
9
0
0
0
9
9
9
0
0
0
% A
% Cys:
0
9
0
0
0
9
0
0
17
9
0
0
0
0
9
% C
% Asp:
9
9
0
17
0
0
0
0
0
0
9
17
9
0
0
% D
% Glu:
0
0
42
17
0
9
0
9
9
0
17
0
0
25
0
% E
% Phe:
0
0
0
9
0
25
9
0
0
0
0
25
9
0
0
% F
% Gly:
9
9
0
0
9
0
0
9
0
0
42
17
0
0
9
% G
% His:
25
0
0
0
9
0
0
25
17
0
0
0
0
0
0
% H
% Ile:
0
9
0
0
9
0
42
0
9
0
0
9
0
17
17
% I
% Lys:
0
0
9
0
0
0
0
0
0
0
9
0
0
0
42
% K
% Leu:
9
0
17
9
0
0
9
0
34
0
9
9
34
9
0
% L
% Met:
0
0
17
0
0
0
0
0
0
0
0
0
0
0
9
% M
% Asn:
0
25
0
0
0
0
0
0
0
17
0
0
0
0
0
% N
% Pro:
9
9
0
0
34
0
0
0
9
0
0
0
17
42
0
% P
% Gln:
17
0
0
0
0
34
25
0
9
9
0
9
0
0
0
% Q
% Arg:
0
0
0
17
0
0
9
0
0
9
0
0
0
0
0
% R
% Ser:
0
34
0
0
42
0
0
9
0
34
9
0
17
9
9
% S
% Thr:
0
0
17
0
0
0
0
0
0
9
0
0
9
0
0
% T
% Val:
9
0
0
9
0
17
9
17
0
9
0
0
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% W
% Tyr:
9
0
0
9
0
0
0
34
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _